Understanding brain connectivity and development in Chiari Type I Malformation
Official title: Functional Connectivity, Brain Development, and Outcomes in Chiari Type I Malformation
Funded at Washington University · NIH-10876276 · Data updated 2026-11-12
This study is looking at how Chiari Type I Malformation affects the way the brain connects and develops in both kids and adults, and it aims to find helpful markers that can predict how patients will do over time compared to healthy people.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $160,426 |
| NIH project number | 5P01NS131131-02 |
| Project ID | NIH-10876276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals diagnosed with Chiari Type I Malformation, both pediatric and adult populations.
✕Less likely to help
Patients without a diagnosis of Chiari Type I Malformation or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research investigates how Chiari Type I Malformation affects brain connectivity and development in both children and adults. By using advanced neuroimaging techniques like resting state functional MRI and diffusion tensor imaging, the study aims to identify specific imaging markers that can help predict outcomes for patients. Participants will be monitored over time, allowing researchers to compare their brain development with that of healthy individuals. The study also incorporates validated health indices to assess the severity of Chiari malformation and its impact on cognitive and emotional health.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for patients with Chiari Type I Malformation.
How similar studies have gone: Previous research has shown promise in using neuroimaging techniques to understand brain disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Roland, Jarod — Washington University
- Study coordinator: Roland, Jarod
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.