Understanding Brain Connections in Chiari Malformation
Functional Connectivity Markers of Cognitive Network Disfunction in Chiari Malformation
This project uses advanced brain imaging to better understand why children with Chiari malformation experience different symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11124092 on NIH RePORTER |
What this research studies
Chiari malformation is a condition where brain tissue extends into the spinal canal, often causing varied symptoms in children. We are using a special type of MRI called resting state functional MRI (rs-fMRI) to look at how different parts of the brain connect and communicate. By studying these brain connections, we hope to find new ways to explain the wide range of symptoms seen in children with Chiari malformation. We will compare brain imaging and cognitive test results from children with Chiari to those without the condition, both from existing data and new participants. We will also follow some children over time, especially after surgery, to see how their brain connections change.
Who could benefit from this research
Good fit: Children and adolescents with Chiari malformation, both those considering surgery and those not, who are receiving clinical care, would be ideal candidates.
Not a fit: Patients whose Chiari malformation is not causing symptoms or who are outside the pediatric age range may not directly benefit from this specific imaging approach.
Why it matters
Potential benefit: This work could lead to a better understanding of Chiari malformation symptoms, potentially helping doctors personalize treatments for children.
How similar studies have performed: While the use of personalized connectomics for Chiari malformation is a novel approach, functional MRI has been successfully used in other neurological conditions to understand brain function.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Roland, Jarod — Washington University
- Study coordinator: Roland, Jarod
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.