Understanding brain circuits involved in navigation difficulties in Alzheimer's disease
Cell-type-specific dissection of retrosplenial circuits in preclinical models of Alzheimer's disease
This study is looking at how certain brain cells affect the way people with Alzheimer's disease get lost or feel disoriented, with the hope that understanding these cells can help create better treatments for navigation problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10900895 on NIH RePORTER |
What this research studies
This research investigates how specific brain cells in the retrosplenial cortex contribute to spatial disorientation in Alzheimer's disease. By examining preclinical models, the study aims to identify the role of low-rheobase cells in processing orientation information, which is crucial for navigation and memory. The approach involves detailed dissection of brain circuits to understand their dysfunction in Alzheimer's. Patients may benefit from insights that could lead to targeted therapies for navigation-related symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who experience spatial disorientation.
Not a fit: Patients with early-stage Alzheimer's disease who do not exhibit symptoms of spatial disorientation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve navigation and memory function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown that targeting specific brain circuits can lead to improvements in cognitive functions, suggesting potential success for this approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Rybicki-Kler, Chloe Isabella — University of Michigan at Ann Arbor
- Study coordinator: Rybicki-Kler, Chloe Isabella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.