Understanding brain circuits involved in high blood pressure
Interrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertension
This study is looking at how certain brain circuits affect high blood pressure, especially in people who don't respond to usual treatments, to find new ways to help manage their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10978086 on NIH RePORTER |
What this research studies
This research investigates how specific brain circuits that contain angiotensin type-1 and type-2 receptors contribute to hypertension, particularly in patients who do not respond to standard treatments. By studying neurons in the brain that are linked to blood pressure regulation, the researchers aim to identify mechanisms that lead to drug-resistant hypertension. The approach includes using advanced techniques like optogenetics to manipulate these neurons in animal models, which may provide insights into new treatment strategies for patients with high blood pressure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from drug-resistant hypertension.
Not a fit: Patients with hypertension that responds well to standard treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing hypertension, especially for those who currently have limited treatment options.
How similar studies have performed: While the specific approach of targeting these brain circuits is novel, similar research has shown promise in understanding hypertension mechanisms.
Where this research is happening
Atlanta, United States
- Georgia State University — Atlanta, United States (Active)
Researchers
- Principal investigator: De Kloet, Annette Diane — Georgia State University
- Study coordinator: De Kloet, Annette Diane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.