Understanding brain circuitry to improve treatment for early psychosis
Cerebellar-Cortical Circuitry and Treatment Response in Early Psychosis
['FUNDING_R01'] · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · NIH-11130544
This study is looking at how certain brain patterns can help doctors figure out which patients with early psychosis will benefit most from antipsychotic medications, so they can create better treatment plans and improve patients' lives.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (MANHASSET, UNITED STATES) |
| Trial ID | NIH-11130544 on ClinicalTrials.gov |
What this research studies
This research investigates how specific brain circuitry can predict how well patients with early psychosis respond to antipsychotic medications. By using advanced imaging techniques like functional magnetic resonance imaging (fMRI), the study aims to identify biomarkers that can help doctors tailor treatment plans more effectively. The research will involve collecting data from a larger group of first-episode psychotic patients to validate these biomarkers, making the process more patient-friendly by using natural stimuli during imaging. Ultimately, the goal is to enhance the quality of life for patients by reducing the time spent on ineffective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing their first episode of psychosis who are beginning treatment with antipsychotic medications.
Not a fit: Patients who have not experienced a first episode of psychosis or those who are not starting antipsychotic treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment plans for patients with early psychosis.
How similar studies have performed: Previous research has shown promise in using brain connectivity as predictive biomarkers for treatment response, indicating that this approach may be effective.
Where this research is happening
MANHASSET, UNITED STATES
- FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH — MANHASSET, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAO, HENGYI — FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: CAO, HENGYI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.