Understanding brain circuit problems in a mouse model of epilepsy
Cortico-hippocampal circuit dysfunction in an Scn1a mouse model of epilepsy
This study is looking at how certain brain pathways change in mice that have epilepsy, with the hope of finding new treatments that could help people living with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10867319 on NIH RePORTER |
What this research studies
This research investigates how specific brain circuits are affected in a mouse model that mimics epilepsy. Using advanced techniques like optogenetics and large-scale imaging, the researchers aim to uncover the underlying mechanisms of epilepsy. The goal is to develop targeted therapies that could improve treatment options for patients with epilepsy. This work is part of a broader training program to prepare the researcher for leading independent studies in this field.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with epilepsy or those who have a genetic predisposition to epilepsy.
Not a fit: Patients with epilepsy caused by factors unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the management and treatment of epilepsy in patients.
How similar studies have performed: Previous research using similar approaches in animal models has shown promise in understanding epilepsy, suggesting that this line of inquiry could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Mattis, Joanna H — University of Michigan at Ann Arbor
- Study coordinator: Mattis, Joanna H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.