Understanding brain circuit issues in mice with chemotherapy-related cognitive problems
Official title: Characterizing Entorhinal Cortex Circuit Dysfunction in an APOE Mouse Model of Chemotherapy-Induced Cognitive Impairment
Funded at Georgetown University · NIH-11088247 · Data updated 2026-11-12
This study is looking at how chemotherapy might impact brain function, especially in areas important for memory, in mice that have a genetic risk for Alzheimer's disease, to help us understand why some cancer survivors may experience memory problems after treatment.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | May 3, 2023 |
| Project end | May 2, 2028 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30AG082448-03 |
| Project ID | NIH-11088247 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who have undergone chemotherapy and may have genetic risk factors for cognitive impairment, particularly those with the APOE4 allele.
✕Less likely to help
Patients who have not undergone chemotherapy or do not carry the APOE4 allele may not benefit from this research.
What this research studies
This research investigates how chemotherapy affects brain function, particularly focusing on the entorhinal cortex, which is crucial for memory and learning. It uses a mouse model that mimics the genetic risk associated with Alzheimer's disease, specifically looking at the APOE4 gene. The study aims to understand how this gene influences brain circuitry and neuron function after chemotherapy treatment, which could lead to cognitive impairments in cancer survivors. By examining the interactions between chemotherapy and genetic factors, the research seeks to uncover mechanisms that contribute to cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for cognitive impairments in cancer patients after chemotherapy.
How similar studies have gone: Previous research has shown that genetic factors like APOE4 significantly influence cognitive outcomes in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Luo, Nancy — Georgetown University
- Study coordinator: Luo, Nancy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.