Understanding brain circuit issues in a mouse model of chemotherapy-related cognitive problems
Official title: Characterizing Entorhinal Cortex Circuit Dysfunction in an APOE Mouse Model of Chemotherapy-Induced Cognitive Impairment
Funded at Georgetown University · NIH-11300669 · Data updated 2026-11-12
This study is looking at how a specific gene might change brain function in mice that have memory problems after chemotherapy, with the goal of finding ways to help cancer patients who experience similar issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | May 3, 2023 |
| Project end | May 2, 2028 |
| Funding year | 2025 |
| Award (this year) | $10,500 |
| NIH project number | 3F30AG082448-03S1 |
| Project ID | NIH-11300669 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who carry the APOE4 gene and are experiencing cognitive difficulties after chemotherapy.
✕Less likely to help
Patients who do not carry the APOE4 gene or who have not undergone chemotherapy may not benefit from this research.
What this research studies
This research investigates how the APOE4 gene affects brain circuits in mice that have experienced chemotherapy-induced cognitive impairment (CICI). It focuses on the entorhinal cortex, a brain region important for memory and learning, to understand how chemotherapy impacts neuron function in genetically susceptible mice. By examining the differences in neuron behavior and structure, the study aims to uncover the mechanisms behind cognitive decline in cancer patients. The findings could lead to better understanding and potential interventions for those affected by CICI.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or mitigating cognitive impairment in cancer patients undergoing chemotherapy.
How similar studies have gone: While research on chemotherapy-induced cognitive impairment is ongoing, this specific approach using a mouse model to study the APOE4 gene's effects is relatively novel.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Luo, Nancy — Georgetown University
- Study coordinator: Luo, Nancy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.