Understanding brain circuit disruptions in different autism models
Official title: Identifying Convergent Circuit Disruptions Across Genetically-Distinct Models of Autism
Funded at University of Illinois at Urbana-Champaign · NIH-11136918 · Data updated 2026-11-12
This study is looking at how certain genetic changes linked to autism affect the brain and behavior, using specially bred rats to find out if these changes lead to similar challenges in autism, which could help us find better treatments for people with different types of autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project start | September 22, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $418,076 |
| NIH project number | 5R01HD111753-03 |
| Project ID | NIH-11136918 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorders, particularly those with known genetic mutations.
✕Less likely to help
Patients without a diagnosis of autism spectrum disorder or those whose conditions do not involve genetic mutations related to ASD may not benefit from this research.
What this research studies
This research investigates how different genetic mutations associated with autism spectrum disorders (ASD) affect brain circuits and behavior. By using genetically distinct rat models, the study aims to identify common disruptions in neuronal function that lead to similar behavioral symptoms in autism. The researchers will explore whether these mutations converge on shared mechanisms, which could help in developing effective treatments for various forms of ASD. The approach combines advanced genetic analysis with behavioral assessments to uncover critical insights into the underlying biology of autism.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that are effective across different genetic forms of autism.
How similar studies have gone: Other research has shown promise in identifying shared mechanisms in autism, but this specific approach using genetically distinct models is relatively novel.
Where this research is happening
-
University of Illinois at Urbana-Champaign
Champaign, United States Active
Researchers
- Principal investigator: Auerbach, Benjamin D — University of Illinois at Urbana-Champaign
- Study coordinator: Auerbach, Benjamin D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.