Understanding brain circuit changes in children with absence epilepsy
Development of aberrant cortical interneuron circuitry in genetic mouse models of absence epilepsy
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10819472
This study is looking at how genes might influence brain connections in kids with absence epilepsy, a type of seizure disorder, to help find new ways to treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10819472 on ClinicalTrials.gov |
What this research studies
This research investigates how genetic factors affect the development of brain circuits in children with absence epilepsy, a common seizure disorder. By using genetic mouse models, the study aims to uncover the specific circuit abnormalities that lead to seizures. The researchers will analyze the brain's microcircuits to determine how disruptions in these networks contribute to seizure activity and cognitive impairments. This work could reveal new therapeutic targets for treating absence epilepsy in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who have been diagnosed with absence epilepsy.
Not a fit: Patients with seizure disorders not related to absence epilepsy or those outside the age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve seizure control and cognitive function in children with absence epilepsy.
How similar studies have performed: Other research has shown promise in understanding brain circuitry related to epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIANG, XIAOLONG — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: JIANG, XIAOLONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.