Understanding brain circuit changes in Alzheimer's disease
Automated cell-type specific electrophysiology for understanding circuit dysregulation in Alzheimer's Disease
This study is looking at how certain brain cells change in people with Alzheimer's disease, hoping to find clues about why memory and thinking skills decline, which could help in spotting the disease earlier and finding new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11006571 on NIH RePORTER |
What this research studies
This research investigates how specific brain cells, particularly parvalbumin-expressing interneurons, behave in Alzheimer's disease. By using automated electrophysiology techniques, the study aims to identify changes in the electrical activity of these cells, which may contribute to cognitive decline in patients. The approach involves analyzing brain circuits to understand how they become dysregulated as Alzheimer's progresses. This could lead to insights into early signs of the disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating Alzheimer's disease at earlier stages.
How similar studies have performed: Previous research has shown that understanding circuit dysfunction in neurodegenerative diseases can lead to significant advancements in treatment approaches.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Rowan, Matthew J.m. — Emory University
- Study coordinator: Rowan, Matthew J.m.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.