Understanding brain circuit changes in Alzheimer's disease
Automated cell-type-specific electrophysiology for understanding circuit dysregulation in Alzheimer's Disease
This study is looking at how certain brain cells behave in Alzheimer's disease to understand why thinking and memory can decline, using mice that have similar brain changes to those seen in people with the condition, with the hope of finding new ways to help slow down or prevent the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10525870 on NIH RePORTER |
What this research studies
This research investigates how specific brain cells, particularly parvalbumin-expressing interneurons, behave in Alzheimer's disease. By using advanced techniques to measure electrical activity in these cells, the study aims to uncover how circuit dysfunction contributes to cognitive decline in patients. The approach involves analyzing brain activity patterns in mouse models that mimic Alzheimer's disease, which may provide insights into early signs of the disease. Ultimately, the goal is to identify potential targets for new treatments that could slow down or prevent the progression of Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow the progression of Alzheimer's disease and improve cognitive function in patients.
How similar studies have performed: Previous research has shown promising results in understanding circuit dysregulation in Alzheimer's, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Rowan, Matthew J.m. — Emory University
- Study coordinator: Rowan, Matthew J.m.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.