Understanding Brain Channels in Movement and Hearing Disorders like SCA13
Expression of Ion Channels in the Auditory System
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11115653
This research explores how specific channels in the brain, which are linked to a condition called Spinocerebellar Ataxia Type 13 (SCA13), affect hearing and movement.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11115653 on ClinicalTrials.gov |
What this research studies
Spinocerebellar Ataxia Type 13 (SCA13) is a genetic condition that causes problems with movement and makes it hard to locate sounds. This happens because of changes in a specific type of brain channel called Kv3.1. This project focuses on a related channel, Kv3.3, and how it interacts with a protein called TBK1, which is important for nerve cell communication and structure. We want to understand how these interactions are disrupted in SCA13, especially with a specific mutation that causes a late-onset form of the condition. By studying these processes in detail, we hope to uncover the basic mechanisms behind SCA13 symptoms.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals living with Spinocerebellar Ataxia Type 13 (SCA13) and related neurological conditions.
Not a fit: Patients without conditions related to Kv3.1 or Kv3.3 ion channels may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and potentially treat the movement and hearing problems experienced by people with SCA13.
How similar studies have performed: This work builds upon existing knowledge of ion channels and their role in neurological disorders, investigating a specific mechanism linked to SCA13.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KACZMAREK, LEONARD K — YALE UNIVERSITY
- Study coordinator: KACZMAREK, LEONARD K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.