Understanding brain changes that look like Alzheimer's disease
Diagnosis and Risk factors of hippocampal sclerosis of aging and limbic predominant age related TDP-43 encephalopathy; common Alzheimer’s mimics
This research aims to find ways to identify two brain conditions, HS-A and LATE-NC, that cause memory problems similar to Alzheimer's disease, while patients are still living.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11174458 on NIH RePORTER |
What this research studies
Hippocampal sclerosis of aging (HS-A) and Limbic predominant age related TDP-43 encephalopathy (LATE-NC) are brain conditions that cause memory loss, often mistaken for Alzheimer's disease. Currently, doctors can only confirm these conditions by examining brain tissue after a person has passed away. This makes it hard to offer specific treatments that are being developed for these conditions. Our goal is to discover new methods, like using MRI scans, to diagnose HS-A and LATE-NC in living individuals. This will help ensure people receive the correct diagnosis and appropriate care.
Who could benefit from this research
Good fit: Ideal candidates would be older adults experiencing memory problems or dementia symptoms that might be mistaken for Alzheimer's disease.
Not a fit: Patients whose memory problems are clearly linked to other known causes or who do not have HS-A or LATE-NC may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier and more accurate diagnoses for people experiencing memory loss, allowing them to access specific treatments as they become available.
How similar studies have performed: Previous work in this grant cycle has shown that quantitative methods are more informative and that MRI can detect early signs of HS-A.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Sajjadi, Seyed Ahmad — University of California-Irvine
- Study coordinator: Sajjadi, Seyed Ahmad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.