Understanding brain changes that lead to cannabis withdrawal and craving
Glutamatergic plasticity that drives cannabinoid withdrawal and craving
This work explores how cannabis use during adolescence changes the brain, leading to withdrawal symptoms and cravings that make it hard to stop.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11141883 on NIH RePORTER |
What this research studies
We want to understand how long-term cannabis use in young people affects brain chemistry, specifically in an area called the nucleus accumbens, which is important for reward and motivation. We are looking at how these brain changes contribute to the strong cravings and withdrawal symptoms that people experience when they try to quit. By uncovering these specific brain adaptations, we hope to find new ways to help adolescents overcome cannabis use disorder and prevent relapse.
Who could benefit from this research
Good fit: This research is relevant for adolescents and young adults who have used cannabis, particularly those experiencing withdrawal symptoms or cannabis use disorder.
Not a fit: Patients not experiencing cannabis withdrawal or craving, or those outside the adolescent age range, may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or therapies for cannabis use disorder, especially for young people struggling with withdrawal and cravings.
How similar studies have performed: Currently, there are no approved medications specifically for cannabis use disorder, making this a novel and much-needed area of investigation.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Spencer, Sade Monique — University of Minnesota
- Study coordinator: Spencer, Sade Monique
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.