Understanding brain changes in schizophrenia using advanced modeling techniques.
Biophysical modeling as a translational bridge for understanding neural ensemble alterations in schizophrenia.
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11063977
This study is looking at how schizophrenia affects thinking and memory, and it’s for people with schizophrenia, bipolar disorder, and their families, as it uses brain scans to understand how changes in brain circuits might relate to these cognitive challenges.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11063977 on ClinicalTrials.gov |
What this research studies
This research investigates the cognitive symptoms of schizophrenia, which significantly impact the quality of life for those affected. By employing biophysical modeling, the study aims to bridge the gap between animal studies and human conditions, focusing on how alterations in brain circuits relate to cognitive deficits. The research will analyze data from a large sample of individuals, including those with schizophrenia, bipolar disorder, and their relatives, using advanced imaging techniques to measure brain activity and reliability.
Who could benefit from this research
Good fit: Ideal candidates include adults diagnosed with schizophrenia or bipolar disorder, as well as their first-degree relatives.
Not a fit: Patients with cognitive deficits not related to schizophrenia or bipolar disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cognitive deficits in schizophrenia, potentially informing new treatment strategies.
How similar studies have performed: Previous research using biophysical modeling in animal studies has shown promise, but this approach in humans is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WENGLER, KENNETH — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: WENGLER, KENNETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.