Understanding brain changes in schizophrenia using advanced modeling techniques.
Official title: Biophysical modeling as a translational bridge for understanding neural ensemble alterations in schizophrenia.
Funded at Icahn School of Medicine at Mount Sinai · NIH-11063977 · Data updated 2026-11-12
This study is looking at how schizophrenia affects thinking and memory, and it’s for people with schizophrenia, bipolar disorder, and their families, as it uses brain scans to understand how changes in brain circuits might relate to these cognitive challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $654,490 |
| NIH project number | 5R01MH134973-02 |
| Project ID | NIH-11063977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults diagnosed with schizophrenia or bipolar disorder, as well as their first-degree relatives.
✕Less likely to help
Patients with cognitive deficits not related to schizophrenia or bipolar disorder may not benefit from this research.
What this research studies
This research investigates the cognitive symptoms of schizophrenia, which significantly impact the quality of life for those affected. By employing biophysical modeling, the study aims to bridge the gap between animal studies and human conditions, focusing on how alterations in brain circuits relate to cognitive deficits. The research will analyze data from a large sample of individuals, including those with schizophrenia, bipolar disorder, and their relatives, using advanced imaging techniques to measure brain activity and reliability.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of cognitive deficits in schizophrenia, potentially informing new treatment strategies.
How similar studies have gone: Previous research using biophysical modeling in animal studies has shown promise, but this approach in humans is relatively novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Wengler, Kenneth — Icahn School of Medicine at Mount Sinai
- Study coordinator: Wengler, Kenneth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.