Understanding Brain Changes in People with HIV
Novel pathogenic mechanism of HIV-associated CNS neurological disorders
This research explores a new idea about why many people with HIV still experience brain-related problems, even with effective treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11085999 on NIH RePORTER |
What this research studies
Even though HIV treatments have improved, about half of all people living with HIV still face neurological challenges that affect their learning and thinking. We don't fully understand why these brain issues continue, which makes it hard to find new treatments. This project will explore a new idea that changes in tiny structures within brain cells, called lipid rafts, caused by the HIV virus, might be a central reason for these problems. By understanding this process better, we hope to uncover new ways to help protect the brain health of people with HIV.
Who could benefit from this research
Good fit: This research is relevant for individuals living with HIV who experience neurological symptoms or cognitive difficulties.
Not a fit: Patients without HIV or those not experiencing neurological symptoms related to HIV may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for HIV-associated neurological problems, improving quality of life for many patients.
How similar studies have performed: This project proposes a novel hypothesis regarding the cause of HIV-associated neurological disorders, building on existing knowledge but exploring an untested central mechanism.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Bukrinsky, Michael Ilya — George Washington University
- Study coordinator: Bukrinsky, Michael Ilya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.