Understanding brain changes in Parkinson's disease
Neurophysiological Mechanisms Underlying Parkinsonian Motor Signs
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-10895380
This study looks at how brain activity changes in monkeys with Parkinson's disease, especially when they move or are at rest, to see how treatments like L-dopa affect their motor skills and help us understand the condition better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10895380 on ClinicalTrials.gov |
What this research studies
This research investigates how neuronal activity and connectivity evolve in the brain circuits associated with movement in a model of Parkinson's disease using nonhuman primates. By recording electrical activity from various brain regions during different states, including rest and movement, the study aims to understand the effects of dopaminergic therapy on brain function. The findings could help clarify the mechanisms behind motor symptoms in Parkinson's disease and the impact of treatments like L-dopa. This research employs advanced techniques to gather data on brain activity patterns as the condition progresses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience motor symptoms.
Not a fit: Patients with Parkinson's disease who do not exhibit motor symptoms or those with advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for motor symptoms in Parkinson's disease, enhancing patients' quality of life.
How similar studies have performed: Previous research has shown promising results in understanding brain mechanisms in Parkinson's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VITEK, JERROLD L — UNIVERSITY OF MINNESOTA
- Study coordinator: VITEK, JERROLD L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.