Understanding Brain Changes in Lupus
Assessing Brain Dysfunction in Individuals with SLE: Heterogeneity, Mechanisms and Metrics
['FUNDING_P01'] · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · NIH-11113403
This research aims to better understand why people with lupus experience problems like memory issues, depression, anxiety, and fatigue.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (nih funded) |
| Locations | 1 site (MANHASSET, UNITED STATES) |
| Trial ID | NIH-11113403 on ClinicalTrials.gov |
What this research studies
We are exploring the biological reasons behind brain-related challenges in individuals with Systemic Lupus Erythematosus (SLE). Our approach involves using a special type of brain scan, called a PET scan, to look at how brain cells communicate. We will also use advanced artificial intelligence to analyze brain imaging data and identify patterns linked to cognitive difficulties, depression, anxiety, and fatigue. This work builds on previous findings and aims to connect brain activity changes with these symptoms, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults, 21 years or older, who have Systemic Lupus Erythematosus (SLE).
Not a fit: Patients without Systemic Lupus Erythematosus or those not experiencing brain-related symptoms may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify and treat the brain-related symptoms that significantly impact the daily lives of people with lupus.
How similar studies have performed: This research builds upon previous findings by the same team regarding metabolic abnormalities in SLE and introduces a novel PET tracer, combining established and new approaches.
Where this research is happening
MANHASSET, UNITED STATES
- FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH — MANHASSET, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACKAY, MEGGAN — FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- Study coordinator: MACKAY, MEGGAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.