Understanding brain changes in epilepsy and their effects on memory and emotions
Official title: Progression of Entorhinal-hippocampal Spatial and Emotional Processing Deficits in a Mouse Model of Temporal Lobe Epilepsy
Funded at Icahn School of Medicine at Mount Sinai · NIH-10929499 · Data updated 2026-11-12
This study is looking at how temporal lobe epilepsy affects brain circuits that help with memory and emotions, using mice to see how these changes might lead to memory problems and mood issues, with the hope of finding better ways to help people with epilepsy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $47,094 |
| NIH project number | 5F99NS135813-02 |
| Project ID | NIH-10929499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy who experience memory and emotional difficulties.
✕Less likely to help
Patients without temporal lobe epilepsy or those whose cognitive and emotional symptoms are not related to epilepsy may not benefit from this research.
What this research studies
This research investigates how temporal lobe epilepsy (TLE) affects specific brain circuits involved in memory and emotional processing. Using a mouse model, the study will examine alterations in the entorhinal-hippocampal circuit, focusing on how these changes contribute to cognitive deficits and psychiatric symptoms associated with epilepsy. Researchers will employ advanced techniques like in vivo calcium imaging to observe brain activity during spatial and memory tasks, comparing epileptic mice to healthy controls. The goal is to uncover the underlying mechanisms that lead to these debilitating comorbidities, which are not effectively treated with current medications.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing memory and emotional issues in patients with temporal lobe epilepsy.
How similar studies have gone: Previous research has shown promising results in understanding brain circuit alterations in epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Soler, Ivan — Icahn School of Medicine at Mount Sinai
- Study coordinator: Soler, Ivan
Related research
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New MRI tools to better plan pediatric epilepsy surgery
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Sahel Epilepsy Study: finding patterns in epilepsy in rural Africa and its links to genes
A plan to study epilepsy in rural Nigeria to discover how common it is, what factors affect risk, and how genetics may influence it, with results that could improve care for people with epilepsy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.