Understanding brain changes in early signs of Parkinson's disease
Neuroplasticity and the emergence of motor and cognitive deficits in prodromal synucleinopathy
This study is looking at how the brain changes in people with isolated rapid eye movement behavior disorder (iRBD), which can be an early sign of Parkinson's disease, to help us find better ways to diagnose and treat those at risk before they show any major symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10419719 on NIH RePORTER |
What this research studies
This research investigates how the brain adapts during the early stages of synucleinopathies, such as Parkinson's disease, by studying individuals with isolated rapid eye movement behavior disorder (iRBD). It aims to understand the structural and functional changes in the brain that occur before the onset of noticeable motor and cognitive symptoms. Using advanced imaging techniques like MRI and EEG, the study will track these changes over time to better understand their role in disease progression. The ultimate goal is to improve early diagnosis and treatment strategies for those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with isolated rapid eye movement behavior disorder (iRBD).
Not a fit: Patients who do not have iRBD or other related synucleinopathies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective interventions for patients at risk of developing Parkinson's disease and related disorders.
How similar studies have performed: Other research has shown promising results in understanding neuroplasticity in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Mackinnon, Colum D — University of Minnesota
- Study coordinator: Mackinnon, Colum D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.