Understanding brain changes in Alzheimer's disease through advanced imaging techniques
Longitudinal Molecular Imaging of Neuropathology and Serotonin in Mild Cognitive Impairment
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10352374
This study is looking at how changes in brain chemicals, like serotonin, can help us spot early signs of Alzheimer's disease in people with mild cognitive impairment, so we can find better ways to detect and treat the condition before it gets worse.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10352374 on ClinicalTrials.gov |
What this research studies
This research uses advanced molecular imaging methods to visualize changes in the brain associated with Alzheimer's disease, particularly in its early stages. By studying how certain brain chemicals, like serotonin, change over time in individuals with mild cognitive impairment, the research aims to identify those at risk for developing Alzheimer's. The goal is to improve early detection and treatment strategies, potentially preventing further cognitive decline. Participants will undergo imaging tests that can reveal important information about their brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing mild cognitive impairment or those at risk for Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for Alzheimer's disease, improving quality of life for patients.
How similar studies have performed: Previous research using molecular imaging techniques has shown promise in understanding Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMITH, GWENN S — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SMITH, GWENN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease