Understanding Brain Changes in Alzheimer's Disease
Neuropathology Core
This core facility helps researchers understand how genes like APOE affect brain changes in Alzheimer's disease and other conditions related to aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11105806 on NIH RePORTER |
What this research studies
This core provides essential support for a larger research effort focused on Alzheimer's disease. We carefully examine brain tissue samples after death to understand how different factors, especially the APOE gene, contribute to the disease. By studying these samples, we can measure levels of key proteins like apoE, amyloid, and tau, as well as markers for inflammation and blood vessel health. This work helps us identify the specific brain changes linked to Alzheimer's and other related conditions, bringing us closer to new insights.
Who could benefit from this research
Good fit: Individuals who have previously donated brain tissue to a brain bank, particularly those with Alzheimer's disease or related conditions, are directly contributing to this research.
Not a fit: Patients seeking direct clinical intervention or treatment will not receive immediate benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of Alzheimer's disease, potentially guiding the development of new ways to prevent or treat it.
How similar studies have performed: The use of neuropathology cores is a well-established and successful approach in Alzheimer's disease research, building on decades of scientific understanding.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Dickson, Dennis William — Mayo Clinic Jacksonville
- Study coordinator: Dickson, Dennis William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.