Understanding brain changes during trauma therapy for adolescents with PTSD

Neural connectivity before and after each of the three treatment phases of trauma-focused therapy for adolescent posttraumatic stress

NIH-funded research University of Texas Hlth Science Center · NIH-11031298

This study is looking at how trauma-focused therapy helps the brains of teenagers with PTSD, so we can learn more about how therapy works and find better ways to help them heal.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Texas Hlth Science Center NIH-funded
Lab location1 site (San Antonio, United States)
Project IDNIH-11031298 on NIH RePORTER

What this research studies

This research investigates how trauma-focused therapy affects the brain of adolescents suffering from posttraumatic stress disorder (PTSD). By using neuroimaging techniques, the study aims to identify specific brain changes that occur during different phases of therapy, which include skill acquisition, narrative processing, and consolidation. The goal is to enhance treatment effectiveness by understanding the neurobiological mechanisms behind successful therapy outcomes. This approach could lead to more personalized and effective treatment strategies for youth with PTSD.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescents aged 12-20 who are experiencing PTSD, particularly those who have not responded well to existing treatments.

Not a fit: Patients outside the age range of 12-20 or those without a diagnosis of PTSD may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved therapeutic approaches that better address the needs of adolescents with PTSD.

How similar studies have performed: Previous research has shown promise in understanding brain changes during therapy, but this study's specific focus on phase-based neuroimaging is relatively novel.

Where this research is happening

San Antonio, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.