Understanding brain changes after oxygen deprivation before birth
Interrogation and Modulation of the Epigenome after Prenatal Hypoxic Brain Injury
This study is looking at how not getting enough oxygen before birth can affect a baby's brain, using a special mouse model to learn about the changes that happen in the brain and how they might lead to problems later on, with the hope of finding ways to help babies who are affected.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10824286 on NIH RePORTER |
What this research studies
This research investigates how a lack of oxygen before birth can lead to long-lasting brain issues in newborns. By using a special mouse model that mimics this condition, the study aims to uncover the biological changes that occur in the brain due to prenatal hypoxia. The researchers will analyze the epigenome, which is responsible for regulating gene expression, to understand how these changes contribute to neurological deficits. This work could provide insights into potential therapeutic targets for improving outcomes in affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and children who have experienced prenatal hypoxic ischemic encephalopathy.
Not a fit: Patients who have not experienced prenatal brain injuries or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate the long-term effects of prenatal brain injuries.
How similar studies have performed: Other research has shown promising results in understanding the epigenetic changes associated with brain injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Cristancho, Ana — Children's Hosp of Philadelphia
- Study coordinator: Cristancho, Ana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.