Understanding Brain Cells in Opioid Withdrawal Discomfort
Morphine-responsive neurons of the medial habenula : a role in aversive states of morphine withdrawal ?
This research explores how specific brain cells might contribute to the uncomfortable feelings people experience when withdrawing from opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Inserm Strasbourg NIH-funded |
| Lab location | 1 site (Strasbourg, France) |
| Project ID | NIH-11092186 on NIH RePORTER |
What this research studies
Opioid withdrawal can be very challenging because of the strong negative emotions it causes. Our scientists believe that a specific group of brain cells, called MHb-MOR neurons, located in a region of the brain known for processing unpleasant feelings, play a crucial role in these difficult experiences. We are using advanced techniques in specially developed mice to either activate or quiet these particular brain cells. By observing how these changes affect withdrawal symptoms, we hope to uncover how these cells contribute to the emotional discomfort of opioid withdrawal.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation but focuses on understanding the brain mechanisms underlying opioid withdrawal.
Not a fit: Patients not experiencing opioid withdrawal or opioid use disorder would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reduce the severe emotional distress associated with opioid withdrawal.
How similar studies have performed: Previous work from this research team and others has identified the medial habenula as important for aversion, and this team has shown these specific neurons modulate aversive states, making this a promising, yet novel, approach.
Where this research is happening
Strasbourg, France
- Inserm Strasbourg — Strasbourg, France (Active)
Researchers
- Principal investigator: Kieffer, Brigitte L. — Inserm Strasbourg
- Study coordinator: Kieffer, Brigitte L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.