Understanding brain cell dysfunction in Fragile X Syndrome
Cortical Interneuron Dysfunction in Fragile X Syndrome
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11046639
This study is looking at how certain brain cells work differently in people with Fragile X Syndrome, which might help us understand why they have trouble processing sensory information, and it could lead to new ways to help improve these challenges.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11046639 on ClinicalTrials.gov |
What this research studies
This research investigates how specific brain cells, known as cortical interneurons, function differently in individuals with Fragile X Syndrome (FXS). By studying animal models, the researchers aim to uncover how these cells develop and connect in the brain, which may lead to sensory processing issues commonly seen in FXS. The study will involve detailed analyses of brain cell behavior and connectivity to understand the underlying mechanisms of sensory hypersensitivity and avoidance behaviors. This research could provide insights into potential therapeutic targets for improving sensory processing in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome, particularly those experiencing sensory processing challenges.
Not a fit: Patients without a diagnosis of Fragile X Syndrome or those who do not exhibit sensory processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve sensory processing and reduce maladaptive behaviors in patients with Fragile X Syndrome.
How similar studies have performed: Previous research has shown promising results in understanding cortical interneuron dysfunction in related conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PORTERA-CAILLIAU, CARLOS — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: PORTERA-CAILLIAU, CARLOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.