Understanding Brain Cell Communication in Parkinson's and Alzheimer's
Mechanisms of Synaptic Dysfunction in Parkinson s and Other Synuclein-Linked Diseases
This research aims to understand how a protein called alpha-synuclein harms brain cell connections in conditions like Parkinson's and Alzheimer's disease, hoping to find ways to fix these problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marine Biological Laboratory NIH-funded |
| Lab location | 1 site (Woods Hole, United States) |
| Project ID | NIH-10694576 on NIH RePORTER |
What this research studies
Many brain conditions, including Parkinson's disease, Lewy body dementia, and some types of Alzheimer's, are linked to a protein called alpha-synuclein building up in brain cells. This buildup particularly affects the connections between brain cells, known as synapses, which are crucial for thinking and memory. We want to discover exactly how alpha-synuclein damages these connections, as current treatments don't address this specific issue. By understanding these detailed processes, we hope to develop new strategies to restore healthy brain cell communication.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying causes of Parkinson's disease, Lewy body dementia, and Alzheimer's disease, as it seeks to understand the basic biology of these conditions.
Not a fit: Patients seeking immediate clinical trials or direct treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that improve thinking, memory, and overall brain function for people living with Parkinson's, Lewy body dementia, and Alzheimer's disease.
How similar studies have performed: Our lab has made initial discoveries in this area, which have been supported by findings in other studies, suggesting a promising path forward.
Where this research is happening
Woods Hole, United States
- Marine Biological Laboratory — Woods Hole, United States (Active)
Researchers
- Principal investigator: Morgan, Jennifer Rebecca — Marine Biological Laboratory
- Study coordinator: Morgan, Jennifer Rebecca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.