Understanding Brain Cell Changes in HIV and Substance Use
Single Cell Transcriptomic and Epigenomic Dissection of Opioid and Cocaine Responses in HIV
This project explores how HIV and drug use, such as opioids and cocaine, affect individual brain cells to better understand conditions like HIV-Associated Neurocognitive Disorders and substance use disorder.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11140288 on NIH RePORTER |
What this research studies
This project aims to understand how HIV infection and substance use disorder (SUD) affect brain cells at a very detailed level. Researchers are looking at the genetic and molecular makeup of individual brain cells to see how they change when someone has HIV and uses substances like opioids or cocaine. This work helps us discover the specific ways these conditions impact different types of brain cells. By understanding these changes, we hope to find new ways to help people living with HIV who also struggle with substance use and related brain issues.
Who could benefit from this research
Good fit: This foundational research does not directly recruit patients but aims to understand the brain changes in individuals affected by HIV and substance use disorder.
Not a fit: Patients not affected by both HIV and substance use disorder would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or ways to manage brain-related problems for people living with HIV and substance use disorder.
How similar studies have performed: While general research exists on HIV and substance use, this project uses advanced single-cell technologies to provide a novel, highly detailed view of brain changes.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Kellis, Manolis — Broad Institute, INC.
- Study coordinator: Kellis, Manolis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.