Understanding Brain Blood Flow in CADASIL
Cerebrovascular reactivity as a VCID biomarker in CADASIL
This project looks at how blood vessels in the brain react in people with CADASIL, a genetic condition that can lead to stroke and memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11194299 on NIH RePORTER |
What this research studies
CADASIL is a genetic condition that can cause strokes and lead to memory and thinking problems. We know that specific changes in a gene called NOTCH3 affect the small blood vessels in the brain. This project will examine how well these small brain blood vessels respond to signals in people with CADASIL, using a measurement called cerebrovascular reactivity (CVR). By studying CVR in adults with CADASIL and NOTCH3 mutations, we hope to find early signs of disease changes before symptoms become noticeable. This work aims to understand how brain blood flow is affected in CADASIL to potentially identify problems sooner.
Who could benefit from this research
Good fit: People with CADASIL who have NOTCH3 mutations, and healthy individuals, are the focus of this research.
Not a fit: Patients without CADASIL or those with different types of dementia may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help identify early signs of vascular dementia in CADASIL patients, potentially leading to earlier interventions.
How similar studies have performed: While the specific use of CVR as an early biomarker in CADASIL is being explored, preclinical studies have indicated a link between NOTCH3 mutations and vascular changes, suggesting a strong basis for this approach.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Barnes, Jill Nicole — University of Wisconsin-Madison
- Study coordinator: Barnes, Jill Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.