Understanding Brain Blood Flow and Thinking Skills After Traumatic Brain Injury
Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury (CAPCOG-TBI)
This work looks at how blood flow in the brain changes after a moderate to severe head injury and how those changes connect to memory and thinking abilities over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11099994 on NIH RePORTER |
What this research studies
We know that traumatic brain injury (TBI) can lead to long-term challenges with thinking and memory, and it might even increase the risk for Alzheimer's disease later in life. This project aims to understand if problems with how blood flows in the brain right after a TBI, and how well it recovers, are linked to a person's cognitive abilities and brain health a year later. We want to find out if these early brain blood flow issues contribute to ongoing cognitive problems or even neurodegeneration. By studying these connections, we hope to identify new ways to help TBI survivors maintain their brain health.
Who could benefit from this research
Good fit: Ideal candidates for related future studies would be adults aged 21 and older who have experienced a moderate to severe traumatic brain injury.
Not a fit: Patients without a history of traumatic brain injury or those outside the specified age range may not directly benefit from this particular line of research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose and potentially treat long-term cognitive issues and reduce the risk of Alzheimer's disease after a traumatic brain injury.
How similar studies have performed: Mounting evidence suggests a link between cerebrovascular dysfunction, TBI, and Alzheimer's disease, and this work aims to fill specific knowledge gaps in this area.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Ding, Kan — Ut Southwestern Medical Center
- Study coordinator: Ding, Kan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.