Understanding Brain Blood Flow and Memory Loss
Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCID
This research aims to understand how blood flow in the brain supports brain activity and how problems with this process contribute to memory loss and dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-11111284 on NIH RePORTER |
What this research studies
Our brains need a constant supply of oxygen and nutrients, which is delivered by blood flow that increases when brain cells are active. This process, called neurovascular coupling, is vital for healthy brain function, and when it goes wrong, it can lead to problems with thinking and memory, including dementia. We are working to uncover the detailed mechanisms of how tiny blood vessels in the brain respond to brain cell activity. By creating advanced computer models and studying brain tissue samples, we hope to learn how signals are sent through these vessels to ensure proper blood flow. This deeper understanding could help us identify new ways to protect brain health and prevent cognitive decline.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals affected by or at risk for vascular cognitive impairment and dementia, including Alzheimer's disease.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the causes of vascular cognitive impairment and dementia, potentially opening doors for new treatments.
How similar studies have performed: While the general concept of neurovascular coupling is established, this specific integrated approach to understanding K+-mediated signaling and microvascular network communication is a novel and detailed investigation.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Tsoukias, Nikolaos Michael — Florida International University
- Study coordinator: Tsoukias, Nikolaos Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.