Understanding brain balance issues in schizophrenia
Official title: Generative Modeling of Excitation:Inhibition Balance Abnormalities in Schizophrenia
Funded at Washington University · NIH-11065856 · Data updated 2026-11-12
This study is looking at how differences in brain activity might affect thinking skills in people with schizophrenia, using advanced brain imaging techniques to find better ways to help improve their cognitive function.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31MH136686-01A1 |
| Project ID | NIH-11065856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with schizophrenia who experience cognitive deficits.
✕Less likely to help
Patients without a diagnosis of schizophrenia or those who do not exhibit cognitive deficits may not benefit from this research.
What this research studies
This research investigates how imbalances in brain excitation and inhibition contribute to cognitive deficits in individuals with schizophrenia. By using a novel modeling approach called Mesoscale Individualized Neurodynamic (MINDy) modeling, the study aims to analyze brain activity through functional MRI data to better understand these imbalances. The goal is to develop more effective assessment tools and potentially identify new therapeutic strategies to enhance cognitive function in patients with schizophrenia.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive deficits in schizophrenia, which currently have no FDA-approved medications.
How similar studies have gone: While cognitive deficits in schizophrenia have been studied, this specific modeling approach is relatively novel and has not been extensively tested in prior research.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Pine, Jacob — Washington University
- Study coordinator: Pine, Jacob
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.