Understanding Brain AVMs
BMP and Notch crosstalk in cerebral arteriovenous malformations
This research aims to understand how certain signals in brain cells go wrong, leading to a condition called cerebral arteriovenous malformations (AVMs).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11093372 on NIH RePORTER |
What this research studies
Cerebral AVMs are abnormal tangles of blood vessels in the brain that can cause serious strokes. We know that special cells called endothelial cells play a key role in these malformations. This project explores how two important cell signals, BMP and Notch, interact incorrectly and cause these endothelial cells to change in a harmful way, leading to AVMs. We are also looking into whether blocking a specific protein, HDAC2, can prevent these cell changes and improve AVMs.
Who could benefit from this research
Good fit: This research is relevant to patients, including children, who are affected by cerebral arteriovenous malformations.
Not a fit: Patients without cerebral arteriovenous malformations would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat cerebral AVMs by targeting the specific cell changes that cause them.
How similar studies have performed: While previous studies have highlighted the importance of endothelial cells and signaling pathways in AVMs, this project explores a novel mechanism involving HDAC2 and its inhibition.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Yao, Yucheng — University of California Los Angeles
- Study coordinator: Yao, Yucheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.