Understanding brain and behavior connections in Fragile X Syndrome using mouse models
Network Mechanisms of Neurophysiology and Behavior in mouse models of Fragile X Syndromeme
This study is looking at how the brains of mice with Fragile X Syndrome work to help us understand the sensory and thinking challenges people with this condition face, and it will also test how some medications might improve brain activity and behavior.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10907669 on NIH RePORTER |
What this research studies
This research investigates how brain networks function in mouse models of Fragile X Syndrome (FXS) to better understand sensory and cognitive challenges associated with the condition. By using advanced techniques like electroencephalogram (EEG) recordings, the team aims to identify specific neurophysiological patterns that are common in both mice and FXS patients. The study will also explore how certain drugs affect brain activity and behavior in these mouse models, providing insights that could translate to human treatments. The research is conducted in collaboration with clinicians to ensure that findings are relevant and applicable to patient care.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with Fragile X Syndrome, particularly those aged 21 and younger.
Not a fit: Patients without a diagnosis of Fragile X Syndrome or those who are not within the specified age range may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive and sensory functions in individuals with Fragile X Syndrome.
How similar studies have performed: Previous research has shown promising results in understanding neurophysiological mechanisms in Fragile X Syndrome, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Binder, Devin K — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Binder, Devin K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.