Understanding Brain Aging and Memory
Cognition & Hippocampal/Cortical Systems in Aging
This research explores how normal aging affects brain systems important for memory, aiming to understand why some people experience cognitive decline.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11092169 on NIH RePORTER |
What this research studies
This project takes a detailed look at how aging impacts the brain's memory centers, specifically the hippocampus and cortex. Researchers are using rat models that show individual differences in aging to understand why some maintain sharp memory while others experience decline. They are studying changes in brain activity and structure that are linked to these memory differences. The goal is to apply these findings to help us better understand and address memory challenges in older adults.
Who could benefit from this research
Good fit: While this specific work uses animal models, future related studies might seek older adults interested in contributing to research on memory and brain aging, especially those with or at risk for cognitive changes.
Not a fit: Patients seeking immediate treatment or direct clinical intervention for cognitive decline would not directly benefit from this foundational animal research.
Why it matters
Potential benefit: This work could lead to a deeper understanding of how aging affects memory, potentially paving the way for new ways to support brain health and prevent cognitive decline in humans.
How similar studies have performed: Previous work under this program has successfully translated findings from animal models to human aging studies, suggesting a strong foundation for this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Knierim, James J — Johns Hopkins University
- Study coordinator: Knierim, James J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.