Understanding Brain Aging and Alzheimer's Disease
Multiscale Modeling of Brain Aging and Alzheimer’s Disease with MRI, Pathology and Proteomics
This project aims to better understand how our brains age and how Alzheimer's disease develops, using advanced imaging and biological information.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11187173 on NIH RePORTER |
What this research studies
Our brains change as we get older, but these changes are different for everyone and can be influenced by our genes, environment, and lifestyle. This project uses advanced MRI scans and other biological information to look at brain changes in much greater detail than before. By doing this, we hope to find early signs of accelerated brain aging and the start of Alzheimer's disease. This deeper understanding could help us identify people at risk sooner and develop ways to prevent the disease.
Who could benefit from this research
Good fit: Individuals interested in contributing to research on brain aging and Alzheimer's disease, particularly those who may have participated in studies providing MRI, pathology, or proteomics data, could be relevant.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not find this basic science project beneficial in the short term.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection of Alzheimer's disease and related dementias, allowing for more timely preventive measures.
How similar studies have performed: While previous brain-age research has used standard neuroimaging, this project proposes a novel approach using advanced diffusion MRI for greater sensitivity.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Fieremans, Els — New York University School of Medicine
- Study coordinator: Fieremans, Els
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.