Understanding brain activity related to movement issues in Parkinson's disease
Official title: Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinsons Disease Using Real-Time Neural Control
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10879102 · Data updated 2026-11-12
This study is looking at how certain brain signals are connected to movement problems in people with Parkinson's disease, hoping to find ways to improve treatments like deep brain stimulation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $591,277 |
| NIH project number | 5R01NS129600-02 |
| Project ID | NIH-10879102 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience motor symptoms such as bradykinesia and rigidity.
✕Less likely to help
Patients who do not have Parkinson's disease or those with advanced stages of the disease where motor symptoms are not present may not benefit from this research.
What this research studies
This research investigates how specific brain signals, particularly beta band oscillations in the subthalamic nucleus, relate to movement difficulties in patients with Parkinson's disease. By using advanced techniques to control and measure these brain signals in real-time, the study aims to determine whether changes in these signals directly affect symptoms like bradykinesia and rigidity. The approach combines feedback control engineering with patient-specific computer models to enhance our understanding of Parkinson's disease and improve treatment options such as deep brain stimulation.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for motor symptoms in Parkinson's disease.
How similar studies have gone: Previous research has shown promising results in understanding brain dynamics in Parkinson's disease, but this specific approach using real-time neural control is relatively novel.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Escobar Sanabria, David — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Escobar Sanabria, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.