Understanding Brain Activity in Young People with OCD
Multimodal Investigation of Excitatory/Inhibitory Imbalances and Network Dysfunction Related to Motor Control in OCD Youth: ùH fMRS and fMRI Applications
This project looks at how brain activity is out of balance in young people, aged 12-20, who have Obsessive Compulsive Disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10975357 on NIH RePORTER |
What this research studies
We are using advanced brain imaging techniques, called fMRS and fMRI, to get a clearer picture of how the brain works in young people with OCD. Specifically, we want to understand if certain brain signals, known as excitatory and inhibitory signals, are out of balance in a key brain area called the dorsal anterior cingulate cortex (dACC). This imbalance might explain some of the symptoms of OCD, like obsessions and compulsions, and related anxiety. By looking closely at these brain signals, we hope to uncover new ways to help young people manage their condition.
Who could benefit from this research
Good fit: Ideal candidates are young people between 12 and 20 years old who have been diagnosed with Obsessive Compulsive Disorder.
Not a fit: Patients outside the 12-20 age range or those without a diagnosis of Obsessive Compulsive Disorder would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the brain changes in OCD, potentially guiding the development of more targeted and effective treatments for young people.
How similar studies have performed: Previous work by this team using similar imaging techniques has already shown general brain chemistry and function differences in the dACC of individuals with OCD, providing a strong foundation for this more detailed investigation.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Rosenberg, David R — Wayne State University
- Study coordinator: Rosenberg, David R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.