Understanding Brain Activity in Movement Difficulties Similar to Parkinson's
Cortical Connectivity and Activity Changes in Motor Preparation and Execution in 6-OHDA-Lesioned Mice
This project uses a mouse model to learn more about how brain activity changes during movement in conditions similar to Parkinson's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11174563 on NIH RePORTER |
What this research studies
We are looking at how brain cells communicate and change their activity when movement becomes difficult, similar to what happens in Parkinson's disease. By studying mice with a condition that mimics Parkinson's, we can observe specific changes in brain circuits that control movement. Our goal is to pinpoint which brain cells and connections are most affected, especially in areas responsible for planning and executing movements. This detailed understanding of brain activity could help us identify new targets for future treatments.
Who could benefit from this research
Good fit: This foundational research is most relevant to patients living with Parkinson's disease or similar movement disorders, as it aims to uncover the underlying brain mechanisms of their condition.
Not a fit: Patients without Parkinson's disease or related movement disorders would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could deepen our understanding of Parkinson's disease at a fundamental level, potentially leading to new strategies for developing treatments that target specific brain circuits.
How similar studies have performed: Previous studies have identified similar pathological activity patterns in primates and human patients with Parkinson's disease, suggesting this approach builds on established observations.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Jaeger, Dieter — Emory University
- Study coordinator: Jaeger, Dieter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.