Understanding Brain Activity in Memory and Motivation
Characterizing the underlying population code to understand the functional organization of the hippocampus and the lateral hypothalamus
This project aims to understand how brain cells work together to influence our choices, especially those related to rewards and substance use.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11131061 on NIH RePORTER |
What this research studies
Our brains have complex ways of processing information, and this project looks at how groups of brain cells, particularly in areas like the hippocampus and lateral hypothalamus, communicate. We want to discover the hidden patterns in these brain signals that guide behaviors like seeking natural rewards versus engaging in drug-seeking. By using advanced imaging and computer models, we hope to uncover the brain's 'code' for these actions. This deeper understanding could help us learn why some behaviors become maladaptive, like in substance use disorders.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but its findings are intended to benefit future patients living with substance use disorders or related conditions.
Not a fit: Patients without substance use disorders or related neurological conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the brain mechanisms behind substance use disorders, paving the way for new and more effective treatments.
How similar studies have performed: This project builds upon recent successes in neural recording technologies and computational methods, applying them in a novel way to understand reward and drug-seeking behaviors.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Nieh, Horng-an Edward — University of Virginia
- Study coordinator: Nieh, Horng-an Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.