Understanding brain activity in children with Fragile X Syndrome
Official title: FX ENTRAIN: Perturbation of neurodynamics underlying sensory hyperarousal and statistical learning in Youth with FXS
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10899435 · Data updated 2026-11-12
This study looks at how the brains of children with Fragile X Syndrome respond to sounds, hoping to understand their unique brain activity better, which could help find new ways to support their learning and sensory experiences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 7, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $712,967 |
| NIH project number | 5R01HD108222-02 |
| Project ID | NIH-10899435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 10 years old diagnosed with Fragile X Syndrome.
✕Less likely to help
Patients who do not have Fragile X Syndrome or are over the age of 10 may not benefit from this research.
What this research studies
This research investigates how brain activity differs in children with Fragile X Syndrome (FXS), particularly focusing on their responses to auditory stimuli. By analyzing brain waves through EEG, the study aims to identify the unique neurodynamics that contribute to sensory and cognitive challenges faced by these children. The research will explore both group trends and individual variations in brain function, which may lead to new therapeutic approaches for improving sensory processing and cognitive abilities in affected youth.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance sensory processing and cognitive function in children with Fragile X Syndrome.
How similar studies have gone: While there has been extensive research on Fragile X Syndrome, this specific approach to understanding neurodynamics in children is relatively novel and has not been extensively tested.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Pedapati, Ernest Vijay — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Pedapati, Ernest Vijay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.