Understanding brain activity in Alzheimer's disease and mild cognitive impairment
Aberrant cortical entrainment in biomarker-confirmed Alzheimer's disease and mild cognitive impairment
This study is looking at how brain activity changes in people with Alzheimer's disease and mild cognitive impairment, and it aims to see if certain visual exercises can help clear out harmful proteins and boost thinking skills.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Father Flanagan's Boys' Home NIH-funded |
| Lab location | 1 site (Boys Town, United States) |
| Project ID | NIH-10994603 on NIH RePORTER |
What this research studies
This research investigates how brain activity, specifically gamma-band neural oscillations, is disrupted in individuals with Alzheimer's disease (AD) and mild cognitive impairment (MCI). By using visual stimulation techniques, the study aims to enhance the clearance of harmful proteins associated with these conditions and improve cognitive functions. The research will involve detailed assessments of brain activity in response to visual tasks to better understand the underlying neurophysiological mechanisms. This could lead to new insights into how to support cognitive health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who have been diagnosed with Alzheimer's disease or mild cognitive impairment.
Not a fit: Patients with other forms of dementia, such as frontotemporal dementia, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing cognitive decline in patients with Alzheimer's disease and mild cognitive impairment.
How similar studies have performed: Previous studies have shown promising results in animal models regarding the effects of gamma oscillatory activity on cognitive performance, but research in humans is still limited.
Where this research is happening
Boys Town, United States
- Father Flanagan's Boys' Home — Boys Town, United States (Active)
Researchers
- Principal investigator: Springer, Seth D — Father Flanagan's Boys' Home
- Study coordinator: Springer, Seth D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.