Understanding brain activity changes in Alzheimer's disease
Complexity of FMRI in Alzheimer's Disease
This study is looking at how brain activity changes in people with Alzheimer's disease using a safe imaging method, and it aims to create a new tool to help spot early signs of the disease, which could lead to better ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10816545 on NIH RePORTER |
What this research studies
This research investigates how brain activity patterns change in individuals with Alzheimer's disease using advanced imaging techniques. It focuses on resting state fMRI, which measures brain connectivity without the need for radioactive tracers, making it a safer and potentially more accessible option. The study aims to develop a new software tool to analyze the complexity of brain signals, which could provide insights into the early stages of Alzheimer's and help identify individuals at risk. By examining these patterns, researchers hope to uncover important biomarkers that could lead to earlier diagnosis and better treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals showing early signs of cognitive decline or those at risk for Alzheimer's disease, particularly those with a family history or genetic predisposition.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of Alzheimer's disease, allowing for timely interventions that may slow disease progression.
How similar studies have performed: Previous research has shown promising results using similar fMRI techniques to identify brain changes associated with Alzheimer's, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Jann, Kay — University of Southern California
- Study coordinator: Jann, Kay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.