Understanding brain activity and blood flow changes in Alzheimer's disease
Simultaneous EEG/fMRI to disentangle neural and vascular mechanisms of Alzheimer's disease pathology
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10888372
This study is looking at how the brain works in people with Alzheimer's disease by using special imaging tools to see brain activity and blood flow, with the goal of finding early signs of the disease before symptoms show up, which could help in treating it sooner.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10888372 on ClinicalTrials.gov |
What this research studies
This research investigates the complex mechanisms behind Alzheimer's disease by using advanced imaging techniques, specifically simultaneous EEG and fMRI. By examining how neural activity and blood flow interact in the brain, the study aims to identify early signs of Alzheimer's pathology before symptoms appear. This approach could help in understanding the disease's progression and potentially guide early interventions. Patients may undergo imaging sessions to capture brain activity and vascular responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with early signs of cognitive decline or specific genetic markers.
Not a fit: Patients with advanced Alzheimer's disease or those without any risk factors for the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention strategies for Alzheimer's disease, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using combined imaging techniques to study brain disorders, suggesting that this approach could yield valuable insights into Alzheimer's disease.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SITNIKOVA, TATIANA — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: SITNIKOVA, TATIANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.