Understanding bowel issues after spinal cord injury
Pathophysiological remodeling of the enteric neuromuscular compartment in experimental spinal cord injury
This study is looking into the bowel issues that people with spinal cord injuries often face, aiming to understand how the nerves and muscles in the gut are affected, so we can find better ways to help improve bowel function and make life easier for those patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10574616 on NIH RePORTER |
What this research studies
This research investigates the bowel problems that often occur after spinal cord injuries, focusing on how the enteric nervous system, which controls gut function, is affected. It aims to understand the changes in the gut's nerve and muscle cells that lead to issues like constipation and irregular bowel movements. By studying these changes, the research seeks to identify potential treatments that could improve bowel function and quality of life for patients with spinal cord injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a spinal cord injury and are suffering from bowel dysfunction.
Not a fit: Patients without spinal cord injuries or those who do not experience bowel issues related to their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for bowel dysfunction in spinal cord injury patients.
How similar studies have performed: Previous research has shown promising results in understanding and treating bowel dysfunction in patients with spinal cord injuries, indicating that this approach has potential for success.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Holmes, Gregory M. — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Holmes, Gregory M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.