Understanding Bone-Removing Cells in Aging
Studies of the fate of the osteoclast
This research explores how inflammation and specific immune cells contribute to bone loss as we get older, aiming to find new ways to keep bones strong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11003789 on NIH RePORTER |
What this research studies
Osteoporosis, a common condition in older adults, happens when bone breakdown outpaces bone building. This project explores how ongoing, low-level inflammation in the body contributes to this imbalance by affecting cells that remove bone (osteoclasts) and cells that build bone (osteoblasts). Researchers have found that a protein called TRAF3, which helps control inflammation, is reduced in older bone marrow, leading to the growth of special immune cells that further increase bone breakdown and prevent new bone formation. By understanding these specific pathways, the team hopes to uncover new targets for medicines that could protect bones from age-related weakening.
Who could benefit from this research
Good fit: Patients experiencing age-related bone loss or osteoporosis may eventually benefit from the discoveries made in this fundamental research.
Not a fit: Patients with bone conditions not related to aging or chronic inflammation may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target inflammation and specific immune cells to prevent or reverse age-related osteoporosis.
How similar studies have performed: This research builds upon recent discoveries by the same team and explores novel mechanisms, while also considering existing FDA-approved drugs for new applications.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Boyce, Brendan F — University of Rochester
- Study coordinator: Boyce, Brendan F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.