Understanding bone health issues in people with type 1 diabetes
Origins of Skeletal Fragility in Type 1 Diabetes
This study is looking at how type 1 diabetes can impact bone health, especially by making bones weaker and more likely to break, and it's for people with type 1 diabetes who want to learn more about how their condition affects their bones and what can be done to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11092256 on NIH RePORTER |
What this research studies
This research investigates how type 1 diabetes affects bone health, particularly focusing on decreased bone mineral density and increased risk of fractures. It explores the role of insulin and insulin-like growth factor-1 in bone formation and how their deficiencies contribute to diabetic bone disease. The study uses pre-clinical mouse models and human observational studies to identify the mechanisms behind these skeletal issues. By understanding these pathways, the research aims to find better treatments to improve bone health in individuals with type 1 diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are experiencing bone health issues.
Not a fit: Patients without type 1 diabetes or those who do not have any skeletal health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance bone health and reduce fracture risk for patients with type 1 diabetes.
How similar studies have performed: Previous studies have shown promising results in understanding the relationship between insulin therapy and bone health in diabetic models, indicating potential for success in this research.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Fowlkes, John L — University of Kentucky
- Study coordinator: Fowlkes, John L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.