Understanding bone formation issues in the jaw joint
Mechanisms of heterotopic ossification in TMJ
This study is looking into what causes temporomandibular joint disorder (TMJD), which can make chewing painful, especially in middle-aged adults, by exploring how issues with tendons and bones in the jaw might play a role, so we can find better ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11026370 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind temporomandibular joint disorder (TMJD), a condition that causes severe pain and affects chewing. It focuses on how defects in tendon and tendon-bone connections contribute to the disease, particularly in middle-aged adults. By studying the biological signals and mechanical forces involved, the research aims to uncover the underlying causes of TMJD and improve treatment outcomes. The approach includes examining the effects of specific genetic deficiencies in animal models to understand how these factors lead to abnormal bone growth in the jaw.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 20-40 who experience symptoms of temporomandibular joint disorder.
Not a fit: Patients with TMJD who are outside the age range of 20-40 or those with other unrelated jaw disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options and improved quality of life for patients suffering from TMJD.
How similar studies have performed: Previous studies have shown promising results in understanding similar mechanisms in other conditions, suggesting potential for success in this area as well.
Where this research is happening
Newark, UNITED STATES
- University of Delaware — Newark, United States (Active)
Researchers
- Principal investigator: Lim, Joohyun — University of Delaware
- Study coordinator: Lim, Joohyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.