Understanding bone density loss and fracture risk during menopause
Predicting Fast Bone Mineral Density Decline and Fracture Across the Menopause Transition
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10999375
This study is looking at how to spot women in their 40s and 50s who might quickly lose bone strength during menopause, so we can help prevent fractures before they happen.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10999375 on ClinicalTrials.gov |
What this research studies
This research investigates how to predict rapid declines in bone mineral density (BMD) and the risk of fractures in women transitioning through menopause. By focusing on women in their 40s to 50s, the study aims to identify those at higher risk for significant bone loss. Researchers will utilize a novel bone balance index (BBI) that combines measurements of bone resorption and formation to non-invasively assess bone health. The findings could lead to early interventions that may prevent fractures before they occur.
Who could benefit from this research
Good fit: Ideal candidates for this research are women aged 40 to 50 who are experiencing menopause or are in the early postmenopausal phase.
Not a fit: Patients who are not in the menopausal transition or who are significantly older or younger than the target age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help prevent fractures in postmenopausal women by identifying those at risk for rapid bone loss.
How similar studies have performed: Previous research has shown promise in using bone turnover markers to assess bone health, suggesting that this novel approach may also yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIEH, ALBERT — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: SHIEH, ALBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.